To take the lab origin theory seriously, as Dr. Ruiz proposes, one must investigate scientists who conducted relevant research and have bypassed transparency or federal records retention requirements.
First believed a lab origin was likely and told the NIAID official whose reputation would be undermined if gain-of-function research of concern funded by his agency caused the pandemic.
The DEFUSE proposal is a cornerstone of the lab-origin theory of SARS-CoV-2 that wasn't voluntarily released by researchers but rather was obtained against the will of the researchers by Charles Rixey and Major Joe Murphy collaborating with a group of internet sleuths called DRASTIC. The 2018 DEFUSE grant by Peter Daszak, Ralph Baric, Linfa Wang, Shi ZhengLi, and others proposed to modify bat SARS-related coronaviruses in precisely the ways SARS-CoV-2 is an anomaly among bat SARS-related coronaviruses, thus providing a very clear research program for lab origin theories.
There's more science on the lab origin of SARS-CoV-2, such as the lack of zoonotic evidence we ought to have obtained by now, followups of important zoonotic-origin studies finding their methods biased, flawed, and wrong, and other niche debates that all continued to tilt the scales towards a lab origin.
First efforts to FOIA these agencies resulted in hundreds of pages of redactions, followed by lawsuits to provide unredacted versions, followed by unredacted versions that were more embarrassing for NIAID while also revealing the original reasons for redactions were unjustified, such as Fauci's emails acknowledging that NIAID funded gain-of-function research of concern on SARS-related coronaviruses and that researchers informed him that they believed a lab origin was likely.
Everything about the unusual genome of SARS-CoV-2 makes sense in light of DEFUSE. From the S1/S2 placement of the Spike's furin cleavage site or the PRRAR sequence found in feline coronaviruses purring in the mind of Ralph Baric, to the New England Bioscience order forms for the enzyme "BsmBI" and off-the-record discussions to offshore work to Wuhan, lab-origin theory has made significant advances in our understanding of Covid origins by further investigating the activities and communications of a very small group of researchers who proposed all of these things in 2018 and received funding from NIAID in 2019 before the head of NIAID obfuscated the evidence of a lab origin in 2020.
Taking the lab origin theory seriously requires becoming familiar with the lines of inquiry of lab-origin theory, and those lines of inquiry of lab-origin theory focus on very specific research programs and proposals, researchers and their preferred methods, the genome of SARS-CoV-2 and any signs of unnatural or anomalous features that are incidentally found in research proposals, and more.
https://brownstone.org/articles/the-nature-of-lab-origin-investigations/
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