The Last Chance Of Freedom : Meta-Analyses Confirm Vitamin D Defends Against Covid

Monday, September 5, 2022

In the first meta-analysis, the odds of developing COVID-19 were 1.46 times higher than those with sufficient vitamin D, and the risk of death was 2.07 times higher
The odds of ICU admission based on vitamin D status were 2.63 times higher among those with severe vitamin D deficiency, 2.16 times higher for those with deficiency, and 2.83 times higher in those with insufficient levels
Only 12.19% of patients who received vitamin D required hospitalization compared to 26.27% who did not
There was no question that vitamin D optimization is a crucial component of prevention and treatment

72 observational studies covering 1,976,099 patients met the criteria for inclusion
Compared to those with sufficient vitamin D, the odds of developing COVID-19 among those with deficient or insufficient vitamin D levels were 1.46 times higher
One potential drawback was that all studies ranked "high" for risk of bias
The studies also differed in their definitions of severe illness and vitamin D deficiency/insufficiency, making absolute comparisons difficult

The second study assessed "whether vitamin D status is associated with the COVID-19 severity, defined as ARDS requiring admission to intensive care unit (ICU) or mortality (primary endpoints) and with the susceptibility to SARS-CoV-19-related hospitalization (secondary endpoints)."
54 observational studies included in the study included 1,403,715 patients.
Risk of COVID infection, hospitalization, ICU admission and death during hospitalization were as follows:
Insufficiency - less than 75 nmol/L (30 ng/mL) Deficiency – less than 50 nmol /L (20 ng)/mL
Severe deficiency ≤ 25 nmol/L
Seventeen studies reported an association between vitamin D and SARS infection; nine reported the association with COVID related hospitalization; and 35 reported COVID associated mortality.

The effect of vitamin D supplementation was found to be quite significant - 12.19% of patients who received vitamin D required ICU admission, compared to 26.27% of those who did not.
Data in all six studies strongly favored vitamin D. The ideal dose, however, remains uncertain.

In all, data on vitamin D status was available for 205,565 patients and 2,022 who were given vitamin D supplementation.
Supplementation was associated with a significant lower risk of both COVID-19 severe disease (SRR 0.38, 95% CI 0.20-0.72, 6 studies) and mortality.

The data clearly show vitamin D is strongly correlated with all COVID-19 risks, and we do not actually need randomized controlled trials to draw this conclusion
Most underlying studies are observational, but at the very least knowledge of whether someone supplements D or of their D status is strongly predictive of their COVID risks/outcomes
RCTs are not required for this conclusion to be sound & unquestionable

Dark skin color, increased age, preexisting chronic conditions and vitamin D deficiency are all features of severe COVID disease
Vitamin D deficiency is the only factor that is readily and easily modifiable.
Optimizing vitamin D can be achieved in just a few weeks, thereby significantly lowering your risk of COVID-19.

The ideal way to optimize your vitamin D level is by exposing large portions of bare skin to the sun.
Sun exposure also provides other biological health benefits over and beyond vitamin D production.
One really important health benefit you can only get from sunlight and not oral supplementation is mitochondrial melatonin production.
95% of the melatonin your body produces is made inside your mitochondria in response to near-infrared (IR) radiation from the sun or other near IR sources. Only 5% of melatonin is produced in your pineal gland.

The most important factor when it comes to vitamin D is your blood level, not the dose.
Aim to reach a blood level between 60 ng/mL and 80 ng /mL (150 nmol/L to 200 nmol /L) that is considered to be the low-end cutoff for effective vitamin D supplementation.

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