Two-dose COVID-19 vaccines may after an initial protective window become less effective against symptomatic infection by the Omicron variant than not getting jabbed at all, according to little-noticed findings in a federal study of how well boosters performed against different variants.
The FDA on Monday revoked authorizations for two such treatments against Omicron infections, including the one used by then-President Trump, finding they were "Highly unlikely to be active" against the now-dominant variant.
Pfizer CEO Albert Bourla said earlier this month that its vaccine offers "Limited if any" protection against Omicron, while Moderna's preliminary booster data showed "Low neutralizing antibody levels" against the variant before boosting.
One Israeli study found increased antibodies but not further protection against Omicron in twice-boosted healthcare workers, while another found such elderly people were "Three times more resistant to serious illness" than the single-boosted, the New York Post reported.
'Not distinguishable from 0' While the JAMA study emphasizes the benefits of boosters against Omicron relative to either not getting vaccinated or two doses, researchers conceded that "The higher odds ratios for Omicron suggest less protection for Omicron than for Delta" among the boosted.
The adjusted odds ratio of symptomatic Omicron infection for boosted versus unvaccinated individuals was 0.33, and for boosted versus two-dose recipients, 0.34.
"[T]he CDC is admitting that vaccine efficacy is indistinguishable from zero from omicron?" he wrote.
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Wednesday, January 26, 2022
CDC study suggests unboosted vaccines become worse than nothing against Omicron
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