India last month began boasting that it has created - and its regulatory body approved - the world's first DNA vaccine, ZyCoV-D. The vaccine, developed by a company called Zydus Cadila, expects to have it available for use as early as next month, giving hope to a country that has suffered more than 447,000 deaths at the hand of the virus.
A DNA vaccine is a form of a software vaccine, explained Tel Aviv University's Prof. Jonathan Gershoni.
A software vaccine is one in which scientists vaccinate with the blueprint of the virus - just the DNA or the RNA corresponding to the genes that code for the spike protein - injecting it in a palatable and effective way into the body.
All of the traditional childhood vaccines that exist today are hardware vaccines.
Since the late 1980s, scientists began playing with the idea that there could be applications for injecting DNA or RNA directly - first, in trying to develop gene therapy, and more recently, in the development of what Gershoni calls software vaccines.
"However, the information that flows from the gene needs to be transcribed to create a disposable and intermediate genetic material in the form of RNA. So, RNA in the traditional sense, is simply a disposable copy of the DNA gene."
On the other hand, the RNA is a more direct way of delivering the instruction manual because the ribosomes cannot interact with the DNA. As such, in systems that use DNA as the genetic material being transferred, the next required step, once the DNA has been delivered to the cells, is that those cells have to make RNA copies of the genes.
https://www.technocracy.news/dna-vaccines-changing-the-genetic-makeup-of-humanity/
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