Recent research published in Neurology indicates that certain sugar substitutes might negatively impact long-term brain health, particularly memory and thinking skills.
• The study analyzed seven low- and no-calorie sweeteners: aspartame, saccharin, acesulfame-K, erythritol, xylitol, sorbitol, and tagatose, primarily found in ultra-processed foods and drinks.
• Among the 12,772 adults studied in Brazil, those consuming the highest amounts of artificial sweeteners experienced more rapid cognitive decline, especially those with diabetes.
• Participants completed dietary questionnaires and were tracked over eight years, with cognitive tests measuring memory, language, and thinking abilities.
• The highest sweetener consumers showed a decline in cognitive skills that was 62% faster than the lowest consumers, equivalent to about 1.6 years of aging.
• The study found a noticeable link between high sweetener intake and cognitive decline in individuals under 60, with a stronger impact observed in those with diabetes.
• Researchers did not find a correlation between tagatose consumption and cognitive decline.
• The study indicates a need for further research to understand the effects of various sugar alternatives, such as applesauce or honey, and acknowledges limitations in dietary reporting.
The findings suggest that while low- and no-calorie sweeteners are often viewed as healthy, they may have adverse effects on cognitive health over time, warranting further investigation.
https://medicalxpress.com/news/2025-09-sweet-sugar-substitutes-linked-faster.html
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