The efficacy of Pfizer's mRNA COVID-19 vaccine for the youngest population authorized to receive it turns negative by the sixth week after full vaccination takes effect, according to buried findings in a study of more than 1.2 million New York children since the Omicron variant's emergence.
Image Pfizer COVID vaccine study in kids Pfizer COVID vaccine study in kids New York Department of Health This finding is left out of the abstract and main body of the study.
"These results highlight the potential need to study alternative vaccine dosing for children and the continued importance [of] layered protections, including mask wearing, to prevent infection and transmission," according to the conclusion.
Tweet URL Regardless of the explanation, the New York paper could throw a wrench in COVID vaccine mandate plans in schools.
One explanation for the negative VE might be that "Kids will get infected sooner or later, so the vaccine just postpones it a little." The hospitalization figures were "The only interesting" part of the paper, he said: "Not statistically significant for the 5-11 year olds despite a huge sample size" and still low in the older group.
The results suggest the younger population should not be vaccinated, while the older group would get "No major benefit." The study makes clear there's no "Scientific case" for children to be subject to vaccine requirements, which are "Borderline delusional" in schools, University of California San Francisco epidemiologist Vinay Prasad said in a YouTube video.
The confidence interval for that group not only "Spans the null," meaning vaccines might have no effect, but it's huge: -12% to 75%. That could actually be good news because "There are very few cases in that cohort." Prasad isn't sold that the dosing difference fully explains the VE difference between the younger and older groups: "I'm not sure they have enough power to really see that difference" and may instead be "Anchoring" to statistical noise.
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Wednesday, March 2, 2022
Pfizer's COVID vaccine efficacy goes negative for younger kids, government study finds
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