A new preprint study up for peer review finds billions of residual DNA fragments in COVID-19 mRNA vaccine vials.
A new preprint study up for peer review finds billions of residual DNA fragments in the COVID-19 mRNA vaccine vials.
Why Would There Be DNA in mRNA Vaccines? The mRNA vaccines are made from DNA. Initially, Pfizer reported that it would use a PCR machine to produce the DNA for the mRNA vaccines.
The PCR machine would first make many copies of DNA, and then the same DNA would be sequenced into RNA. However, because this process would not be fast enough to meet demands, Pfizer announced it would use bacteria to mass produce the spike DNA instead. The DNA produced from the bacteria would then be harvested and sequenced to RNA in a machine.
The spike DNA cannot be introduced alone; other sequences-such as the ori, which signals for DNA replication; the SV40 enhancer gene, which encourages more DNA replication; and an antibiotic resistance gene, which helps scientists identify the bacteria that have taken up the gene-would all be introduced together in a circular bacterial DNA. It should be noted that the SV40 enhancer gene is a genetic sequence from the polyomavirus simian virus 40, a DNA virus known to cause cancer in laboratory animals.
Why DNA Impurities in mRNA Vaccines Are Concerning Foreign DNA introduced into the cell alongside the mRNA is at risk of being mistaken as human DNA. If it is, it can then be integrated into the cell's blueprint.
Vials With More DNA Fragments Related to More Adverse Events The research paper further suggested that vials with higher doses of DNA content could potentially cause more adverse reactions like those found on the Vaccine Adverse Reaction Reports System.
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