The efficacy of ivermectin in treating early and mild COVID-19 infections was confirmed in large states such as Uttar Pradesh
- using it in Uttar Pradesh dramatically reduced both the infection rate and the death toll.
- When the Delta variant broke out in 2021 across India, many states offered the prophylactic population-wide
- even among frontline health care workers it proved effective.
Ivermectin-The Wonder Drug
- First used in Japan in the 70s as an anti-parasitic drug, it has made major inroads against two devastating tropical diseases, onchocerciasis and lymphatic filariasis.
- In addition, it is effective against a host of viruses, including HIV-1, yellow fever, malaria, West Nile virus, Zika, dengue fever, etc.
Potential Mechanisms Against COVID
- SARS-CoV-2 is a virus that takes over host cells to multiply in the body.
- If the virus slips past the cell membrane, its top priority is to infiltrate the brain of the cell-the DNA-containing nucleus-to start mass-producing itself.
- Ivermectin prevents the bonding process by interfering with the virus's spike proteins.
Ivermectin Could Reduce Severe Lung Damage in COVID Patients
- White lung syndrome (a hallmark symptom of acute respiratory distress syndrome) now occurring in severe COVID infections in China, is a sign that the virus has deeply infected the lungs and may have caused cytokine storms (a severe immune reaction in the body) in patients.
- Other complications that arise from COVID-19 involving the lungs are pulmonary fibrosis and hypoxia.
Ivermectin Can Reduce Bacterial Co-Infections for COVID Patients
- Bacterial coinfections are common in respiratory viral infections, and patients with COVID-19 are no exception. Patients with co-infections were more likely to die in intensive care than those without.
- Repurposing drugs is the best accelerator for prophylactic development because it can save developers anywhere from three to 12 years as experts can reuse the data from previous clinical trials and other experiments.
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