Demonstrates that SARS-CoV-2 could not have "Jumped" from animals to humans in the way China claims, because it is probably incapable of infecting bats or pangolins, the only two animal hosts that could have harboured the virus.
Most of the research on SARS-CoV-2 has been focussed on the cascade of events regulated by the protein part of the spike glycoprotein, or S-protein, which has two sections, S1, primarily responsible for binding to the human cell and S2, driving fusion with the cell membrane and entry.
Several scientific studies have demonstrated that SARS-CoV-2 already demonstrated high-affinity human binding even in the earliest cases and that it appeared to be "Pre-adapted." for human infection.
The cleavage of the SARS-CoV-2 protein at the S1 and S2 junction facilitates the fusion of the SARS-CoV-2 membrane with the human cell membrane allowing the insertion of viral genetic material for subsequent virus replication and release.
The most astounding finding of the new study is that insertion of the PRRA polybasic cleavage site into the bat RaTG13 coronavirus, the closest known relative to SARS-CoV-2, but lacks the PRRA site, caused the modified RaTG13 to lose its ability to infect both bats and pangolins.
It is highly unlikely that SARS-CoV-2 could have originated naturally in bats or pangolins, if the addition of the PRRA furin polybasic cleavage site selects against the survival of the virus in either animal.
This new study further confirms the claim that SARS-CoV-2, which appears to have the "Backbone" of a bat coronavirus, must have been genetically manipulated in the laboratory.
Most of the research on SARS-CoV-2 has been focussed on the cascade of events regulated by the protein part of the spike glycoprotein, or S-protein, which has two sections, S1, primarily responsible for binding to the human cell and S2, driving fusion with the cell membrane and entry.
Several scientific studies have demonstrated that SARS-CoV-2 already demonstrated high-affinity human binding even in the earliest cases and that it appeared to be "Pre-adapted." for human infection.
The cleavage of the SARS-CoV-2 protein at the S1 and S2 junction facilitates the fusion of the SARS-CoV-2 membrane with the human cell membrane allowing the insertion of viral genetic material for subsequent virus replication and release.
The most astounding finding of the new study is that insertion of the PRRA polybasic cleavage site into the bat RaTG13 coronavirus, the closest known relative to SARS-CoV-2, but lacks the PRRA site, caused the modified RaTG13 to lose its ability to infect both bats and pangolins.
It is highly unlikely that SARS-CoV-2 could have originated naturally in bats or pangolins, if the addition of the PRRA furin polybasic cleavage site selects against the survival of the virus in either animal.
This new study further confirms the claim that SARS-CoV-2, which appears to have the "Backbone" of a bat coronavirus, must have been genetically manipulated in the laboratory.
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